Punky was a cute seven-year-old Chicago girl. Although she had a sunny outlook on life, she had many problems. Abandoned by her parents, Punky and her adorable puppy, Brandon, set up housekeeping in an empty apartment, where they were soon discovered by the building manager, Henry Warnimont, a dour old bachelor. Somehow he persuaded the skeptical authorities to let Punky stay with him for a while, and the little girl began to bring sunshine into Henry's world. Stories revolved around their adjustments to each other, and Henry's professional work as a photographer.

Penelope "Punky" Brewster: Soliel Moon Frye
Henry P. Warnimont: George Gaynes
Mrs. Betty Johnson, RN: Susie Garrett
Cherie Johnson: Cherie Johnson
Margaux Kramer: Ami Foster
Allen Anderson: Casey Ellison(seasons 1-2)
Eddie Malvin: Eddie Deezen (season 1)
Mrs. Kramer: Loyita Chapel (season 1)
Mrs. Morton: Dody Goodman (season 1)
Mike Fulton: T.K. Carter (season 2)